tag:blogger.com,1999:blog-47285018461898368682024-03-21T06:17:48.137-07:00Chips in SpaceWelcome to the CASIS NIH Chips in Space Blog. The intent is to provide a continuing forum for conversation. This is an OPEN blog and so any proprietary or confidential material should be discussed offline and in a private format. Thanks for participating and keep the conversation going.tissuechip hosthttp://www.blogger.com/profile/12474862795758802080noreply@blogger.comBlogger12125tag:blogger.com,1999:blog-4728501846189836868.post-34148958617751378332018-02-01T10:31:00.001-08:002018-02-01T10:31:28.862-08:00Broken Link on RFA-TR-18-001Note: There is a broken link in <a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-18-001.html" style="background-color: white; box-sizing: border-box; color: #428bca; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 13.6px; text-decoration-line: none;">RFA-TR-18-001</a>. The sentence below should direct to the CORRECT link.<br />
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<span style="font-family: Calibri, sans-serif; font-size: 16px; text-size-adjust: auto;">“</span><span style="font-family: Calibri, sans-serif; font-size: 16px; text-size-adjust: auto;"><span style="background-color: white; background-position: initial initial; background-repeat: initial initial; color: #333333; font-family: Helvetica; font-size: 10pt;">Guidelines and suggested templates for milestones can be found </span></span><a href="https://www.ninds.nih.gov/Funding/Apply-Funding/Application-Support-Library/Neural-Prosthetics-Milestones" style="color: #954f72; font-family: Calibri, sans-serif; font-size: 16px; text-size-adjust: auto;"><span style="color: #428bca; font-family: Helvetica; font-size: 10pt; text-decoration-line: none;">here</span></a><span style="font-family: Calibri, sans-serif; font-size: 16px; text-size-adjust: auto;"><span style="background-color: white; background-position: initial initial; background-repeat: initial initial; color: #333333; font-family: Helvetica; font-size: 10pt;"> (please note that this link relates to another initiative and is mentioned here for general guidance).</span>” </span><br />
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<span style="font-family: Calibri, sans-serif; font-size: 16px; text-size-adjust: auto;"><span style="text-size-adjust: auto;"><span style="font-size: 11pt;">The new CORRECT link is here:<span class="Apple-converted-space"> </span></span></span><a href="https://www.ninds.nih.gov/Funding/Apply-Funding/Application-Support-Library/Devices-Milestones" style="color: #954f72; text-size-adjust: auto;"><span style="font-size: 11pt;">https://www.ninds.nih.gov/Funding/Apply-Funding/Application-Support-Library/Devices-Milestones</span></a></span>tissuechip hosthttp://www.blogger.com/profile/12474862795758802080noreply@blogger.com99tag:blogger.com,1999:blog-4728501846189836868.post-43423238329364081662017-12-19T11:17:00.001-08:002017-12-19T11:17:05.242-08:00Notice of Change to Receipt Date on NIH-CASIS Coordinated Microphysiological Systems Program for Translational Research in Space (UG3/UH3 Clinical Trials Not Allowed) (RFA-TR-18-001)<div style="background-color: white; box-sizing: border-box; color: #333333; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 13.6px; margin-bottom: 10px;">
<span class="heading3" style="box-sizing: border-box; color: #993366; font-size: 1.8em;">Notice Number:</span> <span class="noticenum" style="box-sizing: border-box; font-size: 1.5em;"><a href="https://grants.nih.gov/grants/guide/notice-files/NOT-TR-18-014.html" target="_blank">NOT-TR-18-014</a></span></div>
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<span class="heading3" style="box-sizing: border-box; color: #993366; font-size: 1.8em;">Key Dates</span><br style="box-sizing: border-box;" /><strong style="box-sizing: border-box;">Release Date:</strong> December 19, 2017</div>
<span class="heading3" style="background-color: white; box-sizing: border-box; color: #993366; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 1.8em;">Related Announcements</span><br style="background-color: white; box-sizing: border-box; color: #333333; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 13.6px;" /><a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-18-001.html" style="background-color: white; box-sizing: border-box; color: #428bca; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 13.6px; text-decoration-line: none;">RFA-TR-18-001</a><span style="background-color: white; color: #333333; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 13.6px;"></span><br />
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<span class="heading3" style="box-sizing: border-box; color: #993366; font-size: 1.8em;">Issued by</span><br style="box-sizing: border-box;" />National Center for Advancing Translational Sciences (<a href="http://ncats.nih.gov/" style="box-sizing: border-box; color: #428bca; text-decoration-line: none;">NCATS</a>)</div>
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Purpose</div>
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The purpose of this Notice is to change the Receipt date on NIH-CASIS Coordinated Microphysiological Systems Program for Translational Research in Space (UG3/UH3 Clinical Trials Not Allowed) (<a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-18-001.html" style="box-sizing: border-box; color: #428bca; text-decoration-line: none;">RFA-TR-18-001</a>)</div>
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Currently reads<br style="box-sizing: border-box;" />Application due date:<br style="box-sizing: border-box;" />January 16, 2018<br style="box-sizing: border-box;" />Expiration date: <br style="box-sizing: border-box;" />January 17, 2018</div>
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Revised to read:<br style="box-sizing: border-box;" />Application due date:<br style="box-sizing: border-box;" /><em style="box-sizing: border-box;">February 8, 2018</em><br style="box-sizing: border-box;" />Expiration date:<br style="box-sizing: border-box;" /><em style="box-sizing: border-box;">February 9, 2018</em></div>
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All other aspects of the FOA remain unchanged.</div>
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Inquiries</div>
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Please direct all inquiries to:</div>
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Danilo Tagle, Ph.D. <br style="box-sizing: border-box;" />National Center for Advancing Translational Sciences (NCATS)<br style="box-sizing: border-box;" />Telephone: 301-594-8064 <br style="box-sizing: border-box;" />Email: <a href="mailto:Danilo.Tagle@.nih.gov" style="box-sizing: border-box; color: #428bca; text-decoration-line: none;">Danilo.Tagle@.nih.gov</a></div>
tissuechip hosthttp://www.blogger.com/profile/12474862795758802080noreply@blogger.com1541tag:blogger.com,1999:blog-4728501846189836868.post-12957431450505229902017-12-18T04:29:00.003-08:002017-12-18T04:29:57.903-08:00Recording of CASIS - NSF Tissue Engineering and NIH Chips in Space - Informational WebinarPlease visit <a href="https://www.iss-casis.org/research-on-the-iss/solicitations/tissue-engineering-2017/nsf-nih-casis-informational-webinar/" target="_blank">here </a>for a recording of the Dec 14th 2017 informational webinar. You will also find links to all presentations and answers to questions asked during the webinar.<br />
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<br />tissuechip hosthttp://www.blogger.com/profile/12474862795758802080noreply@blogger.com51tag:blogger.com,1999:blog-4728501846189836868.post-35205804735828029272017-12-12T05:24:00.000-08:002017-12-12T05:24:14.652-08:00Register for Informational WebinarWe will host an informational webinar for the Chips in Space 2.0 FOA (<a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-18-001.html" target="_blank">RFA-TR-18-001</a>) on Dec 14th 2017 at 11am. Register <a href="https://register.gotowebinar.com/register/8393155383063413762" target="_blank">here</a>.<br />
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To view the informational webinar we held prior to Chips in Space 1.0 please go <a href="http://casistissuechip.blogspot.com/p/the-following-page-provides-contact.html" target="_blank">here</a>.tissuechip hosthttp://www.blogger.com/profile/12474862795758802080noreply@blogger.com46tag:blogger.com,1999:blog-4728501846189836868.post-42756413061428744232017-12-04T10:07:00.000-08:002017-12-04T10:07:17.295-08:00CASIS, NCATS, and the NIBIB Announce International Space Station Funding Opportunity Focused on Human Physiology Research<div class="MsoNormal" style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0in 0in 0.0001pt; text-size-adjust: auto;">
<b><span style="font-family: Arial, sans-serif;">Kennedy Space Center, FL (December 4, 2017)</span></b><b><span style="font-family: Arial, sans-serif;"> </span></b><span style="font-family: Arial, sans-serif;">—<b><span class="Apple-converted-space"> </span></b>The Center for the Advancement of Science in Space (CASIS), the National Center for Advancing Translational Sciences (NCATS) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB), today announced a<span class="Apple-converted-space"> </span></span><a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-18-001.html" style="color: #954f72;"><span style="color: blue; font-family: Arial, sans-serif;">funding opportunity focused</span></a><span style="font-family: Arial, sans-serif;"><span class="Apple-converted-space"> </span>on human physiology and disease onboard the International Space Station (ISS) U.S. National Laboratory. Both the NCATS and the NIBIB are part of the National Institutes of Health (NIH). Data from this research — which will feature “Tissue Chips” (or “organs-on-chips”) — will help scientists develop and advance novel technologies to improve human health. This announcement is part of a four-year collaboration through which NCATS will provide up to $7.6 million, subject to funding availability, for research investigations onboard the ISS National Laboratory for the benefit of life on Earth.<span class="Apple-converted-space"> </span><o:p></o:p></span></div>
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<span style="font-family: Arial, sans-serif;">The NCATS released the Funding Opportunity Announcement (FOA) in partnership with NIBIB and CASIS to solicit applications through its </span><a href="https://ncats.nih.gov/tissuechip" style="color: #954f72;"><span style="color: blue; font-family: Arial, sans-serif;">Tissue Chip for Drug Screening</span></a><span style="font-family: Arial, sans-serif;"> program for research on microphysiological systems using the ISS National Lab. This FOA is a reissue of the<span class="Apple-converted-space"> </span></span><a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-16-019.html" style="color: #954f72;"><span style="color: blue; font-family: Arial, sans-serif;">FOA released last year</span></a><span style="font-family: Arial, sans-serif;"><span class="Apple-converted-space"> </span>that subsequently resulted in the award of<span class="Apple-converted-space"> </span></span><a href="https://ncats.nih.gov/tissuechip/projects/space2017" style="color: #954f72;"><span style="color: blue; font-family: Arial, sans-serif;">five projects</span></a><span style="font-family: Arial, sans-serif;">. Recent advances in bioengineering have enabled the manufacture of microphysiological systems using human cells on chips representing functional units of an organ, which replicate the physical and biochemical environment in tissues. In parallel, recent developments in stem cell technology now make it possible to cultivate tissues from humans with specific genotypes and/or disease phenotypes. Advancing this research on the ISS National Lab promises to accelerate the discovery of molecular mechanisms that underlie a range of common human disorders, as well as improve understanding of therapeutic targets and treatments in a reduced fluid shear, microgravity environment that recapitulates cellular and tissue matrices on Earth.<o:p></o:p></span></div>
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<span style="font-family: Arial, sans-serif;">“This new funding opportunity in partnership with NIH provides investigators another path to accelerate biomedical research in a microgravity environment, opening a door to new discoveries in space that will improve health on Earth,” said CASIS Deputy Chief Scientist Dr. Michael Roberts. “With the inclusion of the NIBIB leading the development and application of biomedical technologies and NCATS leading the translation of discovery science to new treatments and cures for human disease, the ISS National Lab is proud to be another crucible of medical innovation.”<o:p></o:p></span></div>
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<span style="font-family: Arial, sans-serif;">“This collaboration will allow us to better understand disease processes in a way we never could before, and improve human health by deploying tissue chips technology at the ISS-NL,” said Danilo A. Tagle, Ph.D., NCATS associate director for special initiatives. “Physiological changes, such as aging, tend to be more dramatic under microgravity, and can provide insights that can translate to identifying novel targets for drug discovery and development, and more effective treatments here on Earth. This effort also provides the chance to work with the space implementation engineers and payload developers to transform tissue chips into a turnkey technology.”<o:p></o:p></span></div>
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<span style="font-family: Arial, sans-serif;">“This joint effort is an opportunity to further develop and refine organ-on-a-chip platforms for research in space,” said Šeila Selimović, Ph.D., director of the NIBIB program in Organs on a Chip. “The inclusion of bioengineering approaches in this program will provide unique technologies for improving our understanding of human health and disease.” <o:p></o:p></span></div>
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<span style="font-family: Arial, sans-serif;">CASIS is the nonprofit organization responsible for managing and promoting research onboard the ISS National Lab. NCATS was officially established in fiscal year 2012 to transform the translational science process so that more treatments and cures for disease can be delivered to more patients more quickly. The NIBIB is focused on improving health by leading the development and accelerating the application of biomedical technologies. Through this funding opportunity, CASIS and NASA will facilitate on-orbit access to the ISS National Lab, while NCATS and NIBIB plan to fund the selected projects to advance fundamental science and engineering knowledge. CASIS, NCATS and NIBIB hope to encourage investigators with expertise in materials science, microfabrication, microfluidics, universal media, stem cell technology, tissue engineering, disease modeling, and developing spaceflight experiments for the ISS National Lab to consider applying for funding.<o:p></o:p></span></div>
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<span style="font-family: Arial, sans-serif;">All proposals must be submitted by January 16, 2018.<o:p></o:p></span></div>
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<span style="font-family: Arial, sans-serif;">To visit the funding opportunity, learn how to submit your proposal and get the latest information on this initiative, please visit:<span class="Apple-converted-space"> </span></span><a href="http://www.casistissuechip.blogspot.com/" style="color: #954f72;"><span style="color: blue; font-family: Arial, sans-serif;">www.casistissuechip.blogspot.com</span></a><span style="font-family: Arial, sans-serif;"><o:p></o:p></span></div>
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<span style="font-family: Arial, sans-serif;">To learn more about the on-orbit capabilities of the ISS National Lab, including past research initiatives and available facilities, visit </span><a href="http://www.spacestationresearch.com/" style="color: #954f72;"><span style="color: blue; font-family: Arial, sans-serif;">www.spacestationresearch.com</span></a></div>
tissuechip hosthttp://www.blogger.com/profile/12474862795758802080noreply@blogger.com31tag:blogger.com,1999:blog-4728501846189836868.post-72310218091961479242017-11-30T13:18:00.000-08:002017-11-30T13:18:02.758-08:00CASIS, NCATS, and the NIBIB Announce International Space Station Funding Opportunity Focused on Human Physiology Research
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Name="envelope return"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="footnote reference"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="annotation reference"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="line number"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="page number"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="endnote reference"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="endnote text"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="table of authorities"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="macro"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="toa heading"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Bullet"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Number"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Bullet 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Bullet 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Bullet 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Bullet 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Number 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Number 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Number 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Number 5"/>
<w:LsdException Locked="false" Priority="10" QFormat="true" Name="Title"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Closing"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Signature"/>
<w:LsdException Locked="false" Priority="1" SemiHidden="true"
UnhideWhenUsed="true" Name="Default Paragraph Font"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text Indent"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Continue"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Continue 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Continue 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Continue 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="List Continue 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Message Header"/>
<w:LsdException Locked="false" Priority="11" QFormat="true" Name="Subtitle"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Salutation"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Date"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text First Indent"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text First Indent 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Note Heading"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text Indent 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text Indent 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Block Text"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Hyperlink"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="FollowedHyperlink"/>
<w:LsdException Locked="false" Priority="22" QFormat="true" Name="Strong"/>
<w:LsdException Locked="false" Priority="20" QFormat="true" Name="Emphasis"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Document Map"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Plain Text"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="E-mail Signature"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Top of Form"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Bottom of Form"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Normal (Web)"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Acronym"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Address"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Cite"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Code"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Definition"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Keyboard"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Preformatted"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Sample"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Typewriter"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Variable"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Normal Table"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="annotation subject"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="No List"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Outline List 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Outline List 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Outline List 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Simple 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Simple 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Simple 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Classic 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Classic 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Classic 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Classic 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Colorful 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Colorful 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Colorful 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 6"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 7"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 8"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 6"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 7"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 8"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table 3D effects 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table 3D effects 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table 3D effects 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Contemporary"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Elegant"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Professional"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Subtle 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Subtle 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Web 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Web 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Web 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Balloon Text"/>
<w:LsdException Locked="false" Priority="39" Name="Table Grid"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Theme"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Note Level 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Note Level 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Note Level 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Note Level 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Note Level 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Note Level 6"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Note Level 7"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Note Level 8"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Note Level 9"/>
<w:LsdException Locked="false" SemiHidden="true" Name="Placeholder Text"/>
<w:LsdException Locked="false" Priority="1" QFormat="true" Name="No Spacing"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading"/>
<w:LsdException Locked="false" Priority="61" Name="Light List"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 1"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 1"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 1"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 1"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 1"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 1"/>
<w:LsdException Locked="false" SemiHidden="true" Name="Revision"/>
<w:LsdException Locked="false" Priority="34" QFormat="true"
Name="List Paragraph"/>
<w:LsdException Locked="false" Priority="29" QFormat="true" Name="Quote"/>
<w:LsdException Locked="false" Priority="30" QFormat="true"
Name="Intense Quote"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 1"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 1"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 1"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 1"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 1"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 1"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 1"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 1"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 2"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 2"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 2"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 2"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 2"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 2"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 2"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 2"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 2"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 2"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 2"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 2"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 2"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 2"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 3"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 3"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 3"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 3"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 3"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 3"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 3"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 3"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 3"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 3"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 3"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 3"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 3"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 3"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 4"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 4"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 4"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 4"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 4"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 4"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 4"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 4"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 4"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 4"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 4"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 4"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 4"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 4"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 5"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 5"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 5"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 5"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 5"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 5"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 5"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 5"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 5"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 5"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 5"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 5"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 5"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 5"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 6"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 6"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 6"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 6"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 6"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 6"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 6"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 6"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 6"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 6"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 6"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 6"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 6"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 6"/>
<w:LsdException Locked="false" Priority="19" QFormat="true"
Name="Subtle Emphasis"/>
<w:LsdException Locked="false" Priority="21" QFormat="true"
Name="Intense Emphasis"/>
<w:LsdException Locked="false" Priority="31" QFormat="true"
Name="Subtle Reference"/>
<w:LsdException Locked="false" Priority="32" QFormat="true"
Name="Intense Reference"/>
<w:LsdException Locked="false" Priority="33" QFormat="true" Name="Book Title"/>
<w:LsdException Locked="false" Priority="37" SemiHidden="true"
UnhideWhenUsed="true" Name="Bibliography"/>
<w:LsdException Locked="false" Priority="39" SemiHidden="true"
UnhideWhenUsed="true" QFormat="true" Name="TOC Heading"/>
<w:LsdException Locked="false" Priority="41" Name="Plain Table 1"/>
<w:LsdException Locked="false" Priority="42" Name="Plain Table 2"/>
<w:LsdException Locked="false" Priority="43" Name="Plain Table 3"/>
<w:LsdException Locked="false" Priority="44" Name="Plain Table 4"/>
<w:LsdException Locked="false" Priority="45" Name="Plain Table 5"/>
<w:LsdException Locked="false" Priority="40" Name="Grid Table Light"/>
<w:LsdException Locked="false" Priority="46" Name="Grid Table 1 Light"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark"/>
<w:LsdException Locked="false" Priority="51" Name="Grid Table 6 Colorful"/>
<w:LsdException Locked="false" Priority="52" Name="Grid Table 7 Colorful"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 1"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 1"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 1"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 1"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 1"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 1"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 1"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 2"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 2"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 2"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 2"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 2"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 2"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 2"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 3"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 3"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 3"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 3"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 3"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 3"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 3"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 4"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 4"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 4"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 4"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 4"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 4"/>
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Space (CASIS), the National Center for Advancing Translational Sciences (NCATS)
and the National Institute of Biomedical Imaging and Bioengineering (NIBIB), today
announced a <a href="https://www.blogger.com/null"></a><a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-18-001.html">funding opportunity focused</a> on </span><span style="font-family: "Arial",sans-serif; font-size: 11.0pt; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US;">human physiology and disease onboard the International Space Station
(ISS) U.S. National Laboratory. </span>
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tissuechip hosthttp://www.blogger.com/profile/12474862795758802080noreply@blogger.com53tag:blogger.com,1999:blog-4728501846189836868.post-83353168952163380712017-08-14T11:11:00.000-07:002017-08-14T11:11:10.215-07:002017 Tissue Chips in Space Mission Patch Contest<div>
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Help design the mission patch for an exciting new research program on the International Space Station!</h3>
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<a href="http://woobox.com/45txpn" target="_blank">Contest Website</a></h3>
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To design a meaningful patch, you'll need to understand the mission. <a href="http://www.spacestationexplorers.org/chips-in-space-mission-patch" target="_blank">Learn about tissue chips and why they're being sent to space!</a></div>
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Contestants are encouraged to be as creative as possible in incorporating the Tissue Chips in Space concept into their patch designs. The only limitation is that the design be submitted in JPG, PNG, or GIF file format. <a href="http://get%20inspiration%20from%20this%20video/" target="_blank">Get inspiration from this video </a>showing how Marvel Comics worked with CASIS to design their mission patch!</div>
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August 9 - September 8: Submit your mission patch design (you can enter more than once!)</div>
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September 9 - 16: Vote for your favorite designs in the Gallery</div>
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September 18: Winners for each age group will be announced</div>
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tissuechip hosthttp://www.blogger.com/profile/12474862795758802080noreply@blogger.com13tag:blogger.com,1999:blog-4728501846189836868.post-53410207468660569812017-06-20T07:58:00.000-07:002017-07-05T07:58:47.927-07:00CASIS and NCATS Announce Five Projects Selected from International Space Station Funding Opportunity Focused on Human Physiology Research<b>These initial grants are part of a four-year partnership to fund research onboard the International Space Station U.S. National Laboratory</b><br />
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<b>Kennedy Space Center, FL (June 20, 2017)</b> — The Center for the Advancement of Science in Space (CASIS) and the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH), today announced five grants have been awarded in response to a <a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-16-019.html" target="_blank">funding opportunity</a> focused on human physiology and disease onboard the International Space Station (ISS) U.S. National Laboratory. Data from this research — which will feature “tissue chips” (or “organs-on-chips”) — will help scientists develop and advance novel technologies to improve human health here on Earth. These initial five projects are part of a four-year collaboration through which NCATS will provide two-years of initial funding of approximately $6 million, to use tissue chip technology for translational research onboard the ISS National Laboratory. Awardees will be eligible for a subsequent two years of funding, pending availability of funds, based upon performance and achieving milestones for each project.<br />
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“The opportunity to partner with CASIS to perform tissue chip science on the International Space Station is a remarkable opportunity to understand disease and improve human health,” said NCATS Director Christopher P. Austin, M.D. “Physiological functions in the microgravity of the International Space Station will provide insights that will increase translational effectiveness on earth, including identifying novel targets for drug discovery and development.”<br />
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The NCATS grants will support the following research projects:<br />
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<b>Lung Host Defense in Microgravity</b><br />
G. Scott Worthen, M.D., <a href="http://www.chop.edu/" target="_blank">Children’s Hospital of Philadelphia</a> and Dan Huh, Ph.D., <a href="http://www.upenn.edu/" target="_blank">University of Pennsylvania</a>, (PA)<br />
Implementation Partners: <a href="http://www.staars.space/" target="_blank">Space Technology and Advanced Research Systems</a> (STaARS) and <a href="http://space4p.com/#/" target="_blank">SpacePharma Inc</a><br />
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There is a link between infections and the health of our immune system. Infections are commonly reported onboard spacecraft where exposure to microgravity negatively affects immune system function, but the mechanisms responsible are not well understood. The goals of this project are to test engineered microphysiological systems that model the airway and bone marrow; and to combine the models to emulate and understand the integrated immune responses of the human respiratory system in microgravity.<br />
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<b>Organs-on-Chips as a Platform for Studying Effects of Microgravity on Human Physiology: Blood-Brain Barrier-Chip in Health and Disease</b><br />
Christopher Hinojosa, M.S. and Katia Karalis, D.S., M.D, <a href="https://emulatebio.com/" target="_blank">Emulate</a>, Boston (MA)<br />
Implementation Partner: <a href="http://www.spacetango.com/" target="_blank">SpaceTango</a><br />
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The objective of this project is to validate, optimize and further develop Emulate’s proprietary Organs-On-Chips technology platform for experimentation with human cells in space. The intent is to develop an automated platform and software to accelerate experimentation in space that will become available to the broader scientific community for studies in human physiology and disease in space. The scientific findings will provide new advancements for Earth studies in human disease and drug discovery. The Brain-Chip to be studied in microgravity is a prototype for an organ system centrally positioned in homeostasis and thus, involved in the pathogenesis of multiple types of disease including neurodegeneration, traumatic injury, and cancer.<br />
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<b>Cartilage-Bone-Synovium Microphysiological System: Musculoskeletal Disease Biology in Space</b><br />
Alan Grodzinsky, Sc.D., M.S and Murat Cirit, Ph.D., <a href="http://web.mit.edu/" target="_blank">Massachusetts Institute of Technology</a>, Cambridge (MA)<br />
Implementation Partner: <a href="http://www.techshot.com/" target="_blank">Techshot</a><br />
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This research focuses on a cartilage-bone-synovium joint tissue chip model to study the effects of space flight on musculoskeletal disease biology, motivated by post-traumatic osteoarthritis and bone loss. The effects of pharmacological agents to ameliorate bone and cartilage degeneration will be tested on earth and in the International Space Station, using a quantitative and high-content experimental and computational approach.<br />
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<b>Microgravity as Model for Immunological Senescence and its Impact on Tissue Stem Cells and Regeneration</b><br />
Sonja Schrepfer, M.D., Ph.D., Tobias Deuse, M.D., and Heath J. Mills, Ph.D., <a href="https://www.ucsf.edu/" target="_blank">University of California, San Francisco </a>(CA)<br />
Implementation Partner: <a href="http://www.staars.space/" target="_blank">Space Technology Advanced Research Systems</a> (STaARS)<br />
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Many space-related physiological changes resemble those observed during cellular aging, including defects in bone healing, loss of cardiovascular and neurological capacity, and altered immune function. This project aims to investigate the relationship between an individual’s immune aging and healing outcomes, and to investigate the biology of aging from two directions—not only during its development in microgravity conditions but also during recovery after return to earth’s environment.<br />
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<b>Effects of Microgravity on the Structure and Function of Proximal and Distal Tubule Microphysiological System</b><br />
Jonathan Himmelfarb, M.D., and Ed Kelly, M.S, Ph.D., <a href="https://www.washington.edu/" target="_blank">University of Washington, Seattle</a> (WA)<br />
Implementation Partner: <a href="http://www-bioserve.colorado.edu/" target="_blank">BioServe Space Technologies</a><br />
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When healthy, your two kidneys work together filter about 110 to 140 liters of blood to produce about 1 to 2 liters of urine every day. Dehydration or diseases like diabetes and high blood pressure impair kidney function and result in serious medical conditions including protein in the urine and kidney stones. Like osteoporosis, these conditions are even more common and follow an accelerated time-course in people living in microgravity. This project will send a kidney model to the International Space Station in order to understand how microgravity and other factors affect kidney function, and to use these discoveries to design better treatments for proteinuria, osteoporosis, and kidney stones on earth.<br />
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“Our partnership with NCATS builds upon dramatic results fostered by public and private investment in organ-on-chip research and enables these pioneering researchers the opportunity to leverage the ISS National Laboratory to further advance an integral and burgeoning area of medical discovery to improve human health on Earth,” said CASIS Deputy Chief Scientist Dr. Michael Roberts. “Additionally, through these creative and collaborative partnerships with established granting agencies like the NCATS, the ISS National Lab demonstrates that research in microgravity is a viable setting to push beyond the terrestrial limits of scientific discovery and opportunity.”<br />
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All grants and subsequent flight opportunities are contingent on final contract agreements between the award recipients, NCATS and CASIS.<br />
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For more information on the NCATS Tissue Chip for Drug Screening Program, including Tissue Chips in Space, please visit <a href="https://ncats.nih.gov/tissuechip">https://ncats.nih.gov/tissuechip</a>.<br />
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To learn more about the on-orbit capabilities of the ISS National Lab, including past research initiatives and available facilities, visit <a href="http://www.spacestationresearch.com/">www.spacestationresearch.com</a>.<br />
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<b>About CASIS:</b> The Center for Advancement of Science in Space (CASIS) is the non-profit organization selected to manage the ISS National Laboratory with a focus on enabling a new era of space research to improve life on Earth. In this innovative role, CASIS promotes and brokers a diverse range of research in life sciences, physical sciences, remote sensing, technology development, and education.<br />
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Since 2011, the ISS National Lab portfolio has included hundreds of novel research projects spanning multiple scientific disciplines, all with the intention of benefitting life on Earth. Working together with NASA, CASIS aims to advance the nation’s leadership in commercial space, pursue groundbreaking science not possible on Earth, and leverage the space station to inspire the next generation.<br />
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<b>About the ISS National Laboratory</b>: In 2005, Congress designated the U.S. portion of the International Space Station as the nation's newest national laboratory to maximize its use for improving life on Earth, promoting collaboration among diverse users, and advancing STEM education. This unique laboratory environment is available for use by other U.S. government agencies and by academic and private institutions, providing access to the permanent microgravity setting, vantage point in low Earth orbit, and varied environments of space.tissuechip hosthttp://www.blogger.com/profile/12474862795758802080noreply@blogger.com12tag:blogger.com,1999:blog-4728501846189836868.post-5288150446001684502016-09-29T06:57:00.002-07:002016-09-29T06:58:38.412-07:00<br />
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<span class="s1">NIH-CASIS Coordinated Microphysiological Systems Program for Translational Research in Space (UG3/UH3)</span></h2>
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<span class="s1"><b>Participating Organization(s): </b></span>National Institutes of Health (<a href="http://www.nih.gov/"><span class="s2">NIH</span></a>)</div>
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<span class="s1"><b>Components of Participating Organizations: </b></span>National Center for Advancing Translational Sciences (<a href="http://ncats.nih.gov/"><span class="s2">NCATS</span></a>)</div>
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<span class="s1"><b>Funding Opportunity Announcement (FOA) Number: </b></span><a href="http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-16-019.html" target="_blank">RFA-TR-16-019</a> </div>
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<span class="s1"><b>Funding Opportunity Purpose</b></span></div>
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<span class="s1">The purpose of this FOA is to promote the development of in vitro microphysiological systems in modeling human diseases and conditions that mimic the pathology in major organs and tissues in the human body, when exposed to the extreme environments of space, and the use of these models at the International Space Station-U.S. National Laboratory (ISS-NL) to facilitate the assessment of biomarkers, bioavailability, efficacy, and toxicity of therapeutic agents prior to entry into clinical trials. </span></div>
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<span class="s1">Funds from the NIH will be made available through the UG3/UH3 cooperative agreement mechanism. During the initial two-year UG3 phase, support will be provided to develop robust models that recapitulate the progression and pathology of human diseases and conditions exposed to prolonged microgravity environment. Following administrative review, the two-year UH3 phase will build upon successful UG3 models to demonstrate the functional utility of the models for more defined experiments at the ISS-NL. It is anticipated that these studies will lead to identification of novel treatment mechanisms through better understanding of disease biology, drug screening, assessment of candidate therapies for efficacy and safety assessments, and establishing the pre-clinical foundation that will inform clinical trial design on Earth.</span></div>
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<span class="s1"><b>Application Due Date(s): </b></span><span class="s1">December 15, 2016, by 5:00 PM local time of applicant organization. All </span><span class="s2">types of non-AIDS applications</span><span class="s1"> allowed for this funding opportunity announcement are due on this date.</span></div>
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<span class="s1"><b>Earliest Start Date: </b></span>July 2017</div>
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<b>More Details: </b><a href="http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-16-019.html">http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-16-019.html</a></div>
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tissuechip hosthttp://www.blogger.com/profile/12474862795758802080noreply@blogger.com10tag:blogger.com,1999:blog-4728501846189836868.post-47366049609770125772016-08-16T09:10:00.000-07:002016-09-01T14:13:16.338-07:00<br />
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<span class="s1"><b>Event Information: NIH-CASIS Coordinated Program in Tissue Chip Systems Translational Research in Space Informational Webinar</b></span></h2>
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The following information is reproduced from <a href="https://nih.webex.com/nih/onstage/g.php?MTID=ec8b40c58dbed99eab2265bd65ed9b102" target="_blank">here</a>.</div>
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<span class="s1">Registration is required to join this event. If you have not registered, please do so now <a href="https://nih.webex.com/nih/onstage/g.php?MTID=ec8b40c58dbed99eab2265bd65ed9b102">here</a>.</span><br />
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<span class="s1"><b>Date and time: </b></span>Tuesday, September 6, 2016 1:00 pm Eastern Daylight Time (New York, GMT-04:00) </div>
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<b>Description: </b>The National Center for Advancing Translational Sciences (NCATS) and the Center for the Advancement of Science in Space (CASIS) have partnered to promote a new program for research on the International Space Station United States National Laboratory (ISS-NL). This program will seek to leverage recent advances in tissue engineering and microfabrication to create microphysiological systems and organ-on-chip technology platforms that recapitulate human physiology to understand the molecular basis of human disease and/or the effectiveness of diagnostic markers and therapeutic intervention for disease treatment. </div>
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<span class="s1">A Notice of Intent to Publish was announced with further details on this initiative - <a href="http://grants.nih.gov/grants/guide/notice-files/NOT-TR-16-018.html">http://grants.nih.gov/grants/guide/notice-files/NOT-TR-16-018.html</a>. </span></div>
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This informational webinar will provide interested investigators an opportunity to learn more about the initiative, and meet and interact with personnel that have specific expertise in developing spaceflight experiments for the ISS-NL.<b> </b></div>
tissuechip hosthttp://www.blogger.com/profile/12474862795758802080noreply@blogger.com8tag:blogger.com,1999:blog-4728501846189836868.post-75256321867562552452016-07-12T13:01:00.002-07:002016-07-12T14:41:46.290-07:00<h2>
<span class="s1">Notice of Intent to Publish a Funding Opportunity Announcement for the NIH-CASIS Coordinated Program in Tissue Chip Systems Translational Research in Space(UH2/UH3)</span></h2>
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<span class="s1"><a href="http://grants.nih.gov/grants/guide/notice-files/NOT-TR-16-018.html">http://grants.nih.gov/grants/guide/notice-files/NOT-TR-16-018.html</a></span></div>
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<span class="s2">Notice Number:</span><span class="s3"> </span><span class="s4">NOT-TR-16-018</span></div>
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<span class="s1">Key Dates</span></div>
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<span class="s1"><b>Release Date:</b> July 11, 2016</span></div>
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<span class="s1"><b>Estimated Publication Date of Announcement: </b> August 2016 </span></div>
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<span class="s1"><b>First Estimated Application Due Date: </b>December 2016 </span></div>
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<span class="s1"><b>Earliest Estimated Award Date: </b> July 2017 </span></div>
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<span class="s1"><b>Earliest Estimated Start Date: </b> August 2017<b><br />
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</b></span><span class="s5">Related Announcements</span></div>
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<span class="s1">None </span></div>
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<span class="s1">Issued by</span></div>
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<span class="s1">National Center for Advancing Translational Sciences (<a href="http://ncats.nih.gov/"><span class="s6">NCATS</span></a>)</span></div>
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<span class="s1"><b>Purpose</b></span></div>
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<span class="s1">The National Center for Advancing Translational Sciences (NCATS) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for research on the International Space Station United States National Laboratory (ISS-NL). This opportunity seeks to leverage recent advances in tissue engineering and microfabrication to create microphysiological systems and organ-on-chip technology platforms that recapitulate human physiology to understand the molecular basis of human disease and/or the effectiveness of diagnostic markers and therapeutic intervention for disease treatment. NCATS and the Center for the Advancement of Science in Space (CASIS) share a common interest in translating models of living human tissues on microchips and related novel technologies for the microfabrication of human cell-based systems to the ISS-NL to understand the molecular and cellular basis of human disease in microgravity. CASIS is the nonprofit organization responsible for managing and promoting research onboard the ISS-NL. To that extent, NCATS and CASIS have established a Memorandum of Understanding (MOU) in order to promote communication and interaction among the NIH, CASIS and other research communities, specifically in relation to the NIH NCATS Tissue Chip Program, to facilitate space-related research. Translation of this research to the ISS-NL promises to accelerate the discovery of molecular mechanisms that underlie a range of common human disorders and advance understanding of therapeutic targets and treatments in a reduced fluid shear, microgravity environment that recapitulates cellular and tissue matrices of Earth.</span></div>
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<span class="s1">This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. </span></div>
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<span class="s1">This FOA will utilize the UH2/UH3 activity code. Details of the planned FOA are provided below.</span></div>
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<span class="s1"><b>An informational webinar will be hosted September 6, 2016 from 1pm to 4pm EST</b>. The webinar will provide interested investigators an opportunity to meet and interact with (implementation partners) personnel that have specific expertise in developing spaceflight experiments for the ISS-NL. Additionally a website has been created, <a href="http://www.casistissuechip.blogspot.com/"><span class="s6">http://www.casistissuechip.blogspot.com</span></a>, to facilitate discussions and distribute information relevant to this initiative.</span></div>
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<span class="s1"><b>Research Initiative Details</b></span></div>
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<span class="s1">This Notice encourages investigators with expertise and insights into human microphysiological systems and related technologies that recapitulate human physiology and that can be used to better understand human health and disease to begin to consider applying for this new FOA.</span></div>
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<span class="s1">In addition, collaborative investigations combining expertise in materials science, microfabrication, microfluidics, universal media, stem cell technology, tissue engineering, disease modeling, and developing spaceflight experiments for the ISS-NL will be encouraged; these investigators should also begin considering applying for this application. </span></div>
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<span class="s1">Among the areas of research encouraged in this initiative are translational research examining the mechanisms that underlie the effects of diseases or conditions associated with bone and cartilage, skeletal muscle, brain, gastrointestinal tract, lung, liver, microvasculature, skin, or other tissues due to prolonged exposure to a microgravity environment, as well as research designed to improve the translation of existing knowledge of strategies for the prevention and treatment of such diseases or conditions.</span></div>
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<span class="s1">It is anticipated that the UH2 phase will involve studies on ground development using tissue chip technology under a microgravity environment, flight integration, conducting experiments at the ISS-NL, and post flight analysis. Successful UH2 projects will transition into the UH3 phase for re-flight and additional experiments and analysis.</span></div>
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<span class="s1"><b>APPLICATIONS ARE NOT BEING SOLICITED AT THIS TIME.</b></span></div>
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<span class="s1">Inquiries</span></div>
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<span class="s1">Please direct all inquiries to:</span></div>
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<span class="s1">Danilo A. Tagle, Ph.D.</span></div>
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<span class="s1">National Center for Advancing Translational Sciences (NCATS)</span></div>
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<span class="s1">Telephone: 301-594-8064</span></div>
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<span class="s7">Email: <a href="mailto:danilo.tagle@nih.gov"><span class="s8">danilo.tagle@nih.gov</span></a></span></div>
tissuechip hosthttp://www.blogger.com/profile/12474862795758802080noreply@blogger.com9tag:blogger.com,1999:blog-4728501846189836868.post-87505202857682556112016-04-11T12:04:00.000-07:002016-05-04T12:05:44.339-07:00Notice of Informational Seminar for NIH-CASIS Coordinated Program in Tissue Chip Systems Translational Research in Space<a href="https://grants.nih.gov/grants/guide/notice-files/NOT-TR-16-011.html">https://grants.nih.gov/grants/guide/notice-files/NOT-TR-16-011.html</a><br />
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<span class="heading3" style="box-sizing: border-box; color: #993366; font-size: 1.8em;">Notice Number:</span> <span class="noticenum" style="box-sizing: border-box; font-size: 1.5em;">NOT-TR-16-011</span></div>
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<span class="heading3" style="box-sizing: border-box; color: #993366; font-size: 1.8em;">Key Dates</span><br />
<strong style="box-sizing: border-box;">Release Date:</strong> April 11, 2016</div>
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<span class="heading3" style="box-sizing: border-box; color: #993366; font-size: 1.8em;">Issued by</span><br />
National Center for Advancing Translational Sciences (<a href="http://ncats.nih.gov/" style="box-sizing: border-box; color: #428bca; text-decoration: none;">NCATS</a>) </div>
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Purpose</div>
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The National Center for Advancing Translational Sciences (NCATS) intends to promote a new program for research on the International Space Station United States National Laboratory (ISS-NL). This program will seek to leverage recent advances in tissue engineering and microfabrication to create microphysiological systems and organ-on-chip technology platforms that recapitulate human physiology to understand the molecular basis of human disease and/or the effectiveness of diagnostic markers and therapeutic intervention for disease treatment. NCATS, NASA, and the Center for the Advancement of Science in Space (CASIS) share a common interest in translating models of living human tissues on microchips and related novel technologies for the microfabrication of human cell-based systems to the ISS-NL to understand the molecular and cellular basis of human disease in microgravity. To that extent, NCATS and CASIS have established an MOU in order to promote communication and interaction among the NIH, CASIS and other research communities, specifically in relation to the NIH NCATS Tissue Chip Program to facilitate space-related research. Translation of this research to the ISS-NL promises to accelerate the discovery of molecular mechanisms that underlie a range of common human disorders and advance understanding of therapeutic targets and treatments in a reduced fluid shear, microgravity environment that recapitulates cellular and tissue matrices of Earth.</div>
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An informational webinar will be hosted April 28th, 2016 from 1pm to 4pm EST. The webinar will provide interested investigators an opportunity to meet and interact with personnel that have specific expertise in developing spaceflight experiments for the ISS-NL.</div>
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You must register to attend the webinar. When you click onto the link <a href="https://nih.webex.com/nih/onstage/g.php?d=624768327&t=a" style="box-sizing: border-box; color: #428bca; text-decoration: none;" title="Link to Non-U.S. Government Site">https://nih.webex.com/nih/onstage/g.php?d=624768327&t=a</a>, you will be asked to give your name, email, affiliation and brief description of your expertise. You will need to complete this portion in order to join.</div>
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Inquiries</div>
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Please direct all inquiries to:</div>
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Danilo A. Tagle, Ph.D.<br />
National Center for Advancing Translational Sciences (NCATS)<br />
Telephone: 301-594-8064<br />
Email: <a href="mailto:danilo.tagle@nih.gov" style="box-sizing: border-box; color: #428bca; text-decoration: none;">danilo.tagle@nih.gov</a></div>
tissuechip hosthttp://www.blogger.com/profile/12474862795758802080noreply@blogger.com18