Tuesday, December 19, 2017

Notice of Change to Receipt Date on NIH-CASIS Coordinated Microphysiological Systems Program for Translational Research in Space (UG3/UH3 Clinical Trials Not Allowed) (RFA-TR-18-001)

Notice Number: NOT-TR-18-014
Key Dates
Release Date:   December 19, 2017
Related Announcements
RFA-TR-18-001
Issued by
National Center for Advancing Translational Sciences (NCATS)
Purpose
The purpose of this Notice is to change the Receipt date on NIH-CASIS Coordinated Microphysiological Systems Program for Translational Research in Space (UG3/UH3 Clinical Trials Not Allowed) (RFA-TR-18-001)
Currently reads
Application due date:
January 16, 2018
Expiration date: 
January 17, 2018
Revised to read:
Application due date:
February 8, 2018
Expiration date:
February 9, 2018
All other aspects of the FOA remain unchanged.
Inquiries
Please direct all inquiries to:
Danilo Tagle, Ph.D. 
National Center for Advancing Translational Sciences (NCATS)
Telephone: 301-594-8064 
Email: Danilo.Tagle@.nih.gov

Monday, December 18, 2017

Recording of CASIS - NSF Tissue Engineering and NIH Chips in Space - Informational Webinar

Please visit here for a recording of the Dec 14th 2017 informational webinar.  You will also find links to all presentations and answers to questions asked during the webinar.


Tuesday, December 12, 2017

Register for Informational Webinar

We will host an informational webinar for the Chips in Space 2.0 FOA (RFA-TR-18-001) on Dec 14th 2017 at 11am.   Register here.

To view the informational webinar we held prior to Chips in Space 1.0 please go here.

Monday, December 4, 2017

CASIS, NCATS, and the NIBIB Announce International Space Station Funding Opportunity Focused on Human Physiology Research

Kennedy Space Center, FL (December 4, 2017)  The Center for the Advancement of Science in Space (CASIS), the National Center for Advancing Translational Sciences (NCATS) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB), today announced a funding opportunity focused on human physiology and disease onboard the International Space Station (ISS) U.S. National Laboratory. Both the NCATS and the NIBIB are part of the National Institutes of Health (NIH). Data from this research — which will feature “Tissue Chips” (or “organs-on-chips”) — will help scientists develop and advance novel technologies to improve human health. This announcement is part of a four-year collaboration through which NCATS will provide up to $7.6 million, subject to funding availability, for research investigations onboard the ISS National Laboratory for the benefit of life on Earth. 

The NCATS released the Funding Opportunity Announcement (FOA) in partnership with NIBIB and CASIS to solicit applications through its Tissue Chip for Drug Screening program for research on microphysiological systems using the ISS National Lab. This FOA is a reissue of the FOA released last year that subsequently resulted in the award of five projects. Recent advances in bioengineering have enabled the manufacture of microphysiological systems using human cells on chips representing functional units of an organ, which replicate the physical and biochemical environment in tissues. In parallel, recent developments in stem cell technology now make it possible to cultivate tissues from humans with specific genotypes and/or disease phenotypes. Advancing this research on the ISS National Lab promises to accelerate the discovery of molecular mechanisms that underlie a range of common human disorders, as well as improve understanding of therapeutic targets and treatments in a reduced fluid shear, microgravity environment that recapitulates cellular and tissue matrices on Earth.

“This new funding opportunity in partnership with NIH provides investigators another path to accelerate biomedical research in a microgravity environment, opening a door to new discoveries in space that will improve health on Earth,” said CASIS Deputy Chief Scientist Dr. Michael Roberts. “With the inclusion of the NIBIB leading the development and application of biomedical technologies and NCATS leading the translation of discovery science to new treatments and cures for human disease, the ISS National Lab is proud to be another crucible of medical innovation.”

“This collaboration will allow us to better understand disease processes in a way we never could before, and improve human health by deploying tissue chips technology at the ISS-NL,” said Danilo A. Tagle, Ph.D., NCATS associate director for special initiatives. “Physiological changes, such as aging, tend to be more dramatic under microgravity, and can provide insights that can translate to identifying novel targets for drug discovery and development, and more effective treatments here on Earth. This effort also provides the chance to work with the space implementation engineers and payload developers to transform tissue chips into a turnkey technology.”

“This joint effort is an opportunity to further develop and refine organ-on-a-chip platforms for research in space,” said Å eila Selimović, Ph.D., director of the NIBIB program in Organs on a Chip. “The inclusion of bioengineering approaches in this program will provide unique technologies for improving our understanding of human health and disease.” 

CASIS is the nonprofit organization responsible for managing and promoting research onboard the ISS National Lab. NCATS was officially established in fiscal year 2012 to transform the translational science process so that more treatments and cures for disease can be delivered to more patients more quickly. The NIBIB is focused on improving health by leading the development and accelerating the application of biomedical technologies. Through this funding opportunity, CASIS and NASA will facilitate on-orbit access to the ISS National Lab, while NCATS and NIBIB plan to fund the selected projects to advance fundamental science and engineering knowledge. CASIS, NCATS and NIBIB hope to encourage investigators with expertise in materials science, microfabrication, microfluidics, universal media, stem cell technology, tissue engineering, disease modeling, and developing spaceflight experiments for the ISS National Lab to consider applying for funding.

All proposals must be submitted by January 16, 2018.

To visit the funding opportunity, learn how to submit your proposal and get the latest information on this initiative, please visit: www.casistissuechip.blogspot.com

To learn more about the on-orbit capabilities of the ISS National Lab, including past research initiatives and available facilities, visit www.spacestationresearch.com

Thursday, November 30, 2017

CASIS, NCATS, and the NIBIB Announce International Space Station Funding Opportunity Focused on Human Physiology Research

The Center for the Advancement of Science in Space (CASIS), the National Center for Advancing Translational Sciences (NCATS) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB), today announced a funding opportunity focused on human physiology and disease onboard the International Space Station (ISS) U.S. National Laboratory. 

Monday, August 14, 2017

2017 Tissue Chips in Space Mission Patch Contest


Help design the mission patch for an exciting new research program on the International Space Station!


Contest Website



To design a meaningful patch, you'll need to understand the mission. Learn about tissue chips and why they're being sent to space!

Contestants are encouraged to be as creative as possible in incorporating the Tissue Chips in Space concept into their patch designs. The only limitation is that the design be submitted in JPG, PNG, or GIF file format. Get inspiration from this video showing how Marvel Comics worked with CASIS to design their mission patch!

August 9 - September 8: Submit your mission patch design (you can enter more than once!)
September 9 - 16: Vote for your favorite designs in the Gallery
September 18: Winners for each age group will be announced

Tuesday, June 20, 2017

CASIS and NCATS Announce Five Projects Selected from International Space Station Funding Opportunity Focused on Human Physiology Research

These initial grants are part of a four-year partnership to fund research onboard the International Space Station U.S. National Laboratory


Kennedy Space Center, FL (June 20, 2017) — The Center for the Advancement of Science in Space (CASIS) and the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH), today announced five grants have been awarded in response to a funding opportunity focused on human physiology and disease onboard the International Space Station (ISS) U.S. National Laboratory. Data from this research — which will feature “tissue chips” (or “organs-on-chips”) — will help scientists develop and advance novel technologies to improve human health here on Earth. These initial five projects are part of a four-year collaboration through which NCATS will provide two-years of initial funding of approximately $6 million, to use tissue chip technology for translational research onboard the ISS National Laboratory. Awardees will be eligible for a subsequent two years of funding, pending availability of funds, based upon performance and achieving milestones for each project.

“The opportunity to partner with CASIS to perform tissue chip science on the International Space Station is a remarkable opportunity to understand disease and improve human health,” said NCATS Director Christopher P. Austin, M.D. “Physiological functions in the microgravity of the International Space Station will provide insights that will increase translational effectiveness on earth, including identifying novel targets for drug discovery and development.”

The NCATS grants will support the following research projects:


Lung Host Defense in Microgravity
G. Scott Worthen, M.D., Children’s Hospital of Philadelphia and Dan Huh, Ph.D., University of Pennsylvania, (PA)
Implementation Partners: Space Technology and Advanced Research Systems (STaARS) and SpacePharma Inc

There is a link between infections and the health of our immune system. Infections are commonly reported onboard spacecraft where exposure to microgravity negatively affects immune system function, but the mechanisms responsible are not well understood. The goals of this project are to test engineered microphysiological systems that model the airway and bone marrow; and to combine the models to emulate and understand the integrated immune responses of the human respiratory system in microgravity.


Organs-on-Chips as a Platform for Studying Effects of Microgravity on Human Physiology: Blood-Brain Barrier-Chip in Health and Disease
Christopher Hinojosa, M.S. and Katia Karalis, D.S., M.D, Emulate, Boston (MA)
Implementation Partner: SpaceTango

The objective of this project is to validate, optimize and further develop Emulate’s proprietary Organs-On-Chips technology platform for experimentation with human cells in space. The intent is to develop an automated platform and software to accelerate experimentation in space that will become available to the broader scientific community for studies in human physiology and disease in space. The scientific findings will provide new advancements for Earth studies in human disease and drug discovery. The Brain-Chip to be studied in microgravity is a prototype for an organ system centrally positioned in homeostasis and thus, involved in the pathogenesis of multiple types of disease including neurodegeneration, traumatic injury, and cancer.


Cartilage-Bone-Synovium Microphysiological System: Musculoskeletal Disease Biology in Space
Alan Grodzinsky, Sc.D., M.S and Murat Cirit, Ph.D., Massachusetts Institute of Technology, Cambridge (MA)
Implementation Partner: Techshot

This research focuses on a cartilage-bone-synovium joint tissue chip model to study the effects of space flight on musculoskeletal disease biology, motivated by post-traumatic osteoarthritis and bone loss. The effects of pharmacological agents to ameliorate bone and cartilage degeneration will be tested on earth and in the International Space Station, using a quantitative and high-content experimental and computational approach.



Microgravity as Model for Immunological Senescence and its Impact on Tissue Stem Cells and Regeneration
Sonja Schrepfer, M.D., Ph.D., Tobias Deuse, M.D., and Heath J. Mills, Ph.D., University of California, San Francisco (CA)
Implementation Partner: Space Technology Advanced Research Systems (STaARS)

Many space-related physiological changes resemble those observed during cellular aging, including defects in bone healing, loss of cardiovascular and neurological capacity, and altered immune function. This project aims to investigate the relationship between an individual’s immune aging and healing outcomes, and to investigate the biology of aging from two directions—not only during its development in microgravity conditions but also during recovery after return to earth’s environment.



Effects of Microgravity on the Structure and Function of Proximal and Distal Tubule Microphysiological System
Jonathan Himmelfarb, M.D., and Ed Kelly, M.S, Ph.D., University of Washington, Seattle (WA)
Implementation Partner: BioServe Space Technologies

When healthy, your two kidneys work together filter about 110 to 140 liters of blood to produce about 1 to 2 liters of urine every day. Dehydration or diseases like diabetes and high blood pressure impair kidney function and result in serious medical conditions including protein in the urine and kidney stones. Like osteoporosis, these conditions are even more common and follow an accelerated time-course in people living in microgravity. This project will send a kidney model to the International Space Station in order to understand how microgravity and other factors affect kidney function, and to use these discoveries to design better treatments for proteinuria, osteoporosis, and kidney stones on earth.



“Our partnership with NCATS builds upon dramatic results fostered by public and private investment in organ-on-chip research and enables these pioneering researchers the opportunity to leverage the ISS National Laboratory to further advance an integral and burgeoning area of medical discovery to improve human health on Earth,” said CASIS Deputy Chief Scientist Dr. Michael Roberts. “Additionally, through these creative and collaborative partnerships with established granting agencies like the NCATS, the ISS National Lab demonstrates that research in microgravity is a viable setting to push beyond the terrestrial limits of scientific discovery and opportunity.”

All grants and subsequent flight opportunities are contingent on final contract agreements between the award recipients, NCATS and CASIS.

For more information on the NCATS Tissue Chip for Drug Screening Program, including Tissue Chips in Space, please visit https://ncats.nih.gov/tissuechip.

To learn more about the on-orbit capabilities of the ISS National Lab, including past research initiatives and available facilities, visit www.spacestationresearch.com.


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About CASIS:  The Center for Advancement of Science in Space (CASIS) is the non-profit organization selected to manage the ISS National Laboratory with a focus on enabling a new era of space research to improve life on Earth. In this innovative role, CASIS promotes and brokers a diverse range of research in life sciences, physical sciences, remote sensing, technology development, and education.

Since 2011, the ISS National Lab portfolio has included hundreds of novel research projects spanning multiple scientific disciplines, all with the intention of benefitting life on Earth. Working together with NASA, CASIS aims to advance the nation’s leadership in commercial space, pursue groundbreaking science not possible on Earth, and leverage the space station to inspire the next generation.


About the ISS National Laboratory: In 2005, Congress designated the U.S. portion of the International Space Station as the nation's newest national laboratory to maximize its use for improving life on Earth, promoting collaboration among diverse users, and advancing STEM education. This unique laboratory environment is available for use by other U.S. government agencies and by academic and private institutions, providing access to the permanent microgravity setting, vantage point in low Earth orbit, and varied environments of space.