Thursday, September 29, 2016
Participating Organization(s): National Institutes of Health (NIH)
Components of Participating Organizations: National Center for Advancing Translational Sciences (NCATS)
Funding Opportunity Announcement (FOA) Number: RFA-TR-16-019
Funding Opportunity Purpose
The purpose of this FOA is to promote the development of in vitro microphysiological systems in modeling human diseases and conditions that mimic the pathology in major organs and tissues in the human body, when exposed to the extreme environments of space, and the use of these models at the International Space Station-U.S. National Laboratory (ISS-NL) to facilitate the assessment of biomarkers, bioavailability, efficacy, and toxicity of therapeutic agents prior to entry into clinical trials.
Funds from the NIH will be made available through the UG3/UH3 cooperative agreement mechanism. During the initial two-year UG3 phase, support will be provided to develop robust models that recapitulate the progression and pathology of human diseases and conditions exposed to prolonged microgravity environment. Following administrative review, the two-year UH3 phase will build upon successful UG3 models to demonstrate the functional utility of the models for more defined experiments at the ISS-NL. It is anticipated that these studies will lead to identification of novel treatment mechanisms through better understanding of disease biology, drug screening, assessment of candidate therapies for efficacy and safety assessments, and establishing the pre-clinical foundation that will inform clinical trial design on Earth.
Application Due Date(s): December 15, 2016, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on this date.
Earliest Start Date: July 2017
Tuesday, August 16, 2016
Event Information: NIH-CASIS Coordinated Program in Tissue Chip Systems Translational Research in Space Informational Webinar
The following information is reproduced from here.
Date and time: Tuesday, September 6, 2016 1:00 pm Eastern Daylight Time (New York, GMT-04:00)
Description: The National Center for Advancing Translational Sciences (NCATS) and the Center for the Advancement of Science in Space (CASIS) have partnered to promote a new program for research on the International Space Station United States National Laboratory (ISS-NL). This program will seek to leverage recent advances in tissue engineering and microfabrication to create microphysiological systems and organ-on-chip technology platforms that recapitulate human physiology to understand the molecular basis of human disease and/or the effectiveness of diagnostic markers and therapeutic intervention for disease treatment.
A Notice of Intent to Publish was announced with further details on this initiative - http://grants.nih.gov/grants/guide/notice-files/NOT-TR-16-018.html.
This informational webinar will provide interested investigators an opportunity to learn more about the initiative, and meet and interact with personnel that have specific expertise in developing spaceflight experiments for the ISS-NL.
Tuesday, July 12, 2016
Notice of Intent to Publish a Funding Opportunity Announcement for the NIH-CASIS Coordinated Program in Tissue Chip Systems Translational Research in Space(UH2/UH3)
Notice Number: NOT-TR-16-018
Release Date: July 11, 2016
Estimated Publication Date of Announcement: August 2016
First Estimated Application Due Date: December 2016
Earliest Estimated Award Date: July 2017
Earliest Estimated Start Date: August 2017
National Center for Advancing Translational Sciences (NCATS)
The National Center for Advancing Translational Sciences (NCATS) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for research on the International Space Station United States National Laboratory (ISS-NL). This opportunity seeks to leverage recent advances in tissue engineering and microfabrication to create microphysiological systems and organ-on-chip technology platforms that recapitulate human physiology to understand the molecular basis of human disease and/or the effectiveness of diagnostic markers and therapeutic intervention for disease treatment. NCATS and the Center for the Advancement of Science in Space (CASIS) share a common interest in translating models of living human tissues on microchips and related novel technologies for the microfabrication of human cell-based systems to the ISS-NL to understand the molecular and cellular basis of human disease in microgravity. CASIS is the nonprofit organization responsible for managing and promoting research onboard the ISS-NL. To that extent, NCATS and CASIS have established a Memorandum of Understanding (MOU) in order to promote communication and interaction among the NIH, CASIS and other research communities, specifically in relation to the NIH NCATS Tissue Chip Program, to facilitate space-related research. Translation of this research to the ISS-NL promises to accelerate the discovery of molecular mechanisms that underlie a range of common human disorders and advance understanding of therapeutic targets and treatments in a reduced fluid shear, microgravity environment that recapitulates cellular and tissue matrices of Earth.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
This FOA will utilize the UH2/UH3 activity code. Details of the planned FOA are provided below.
An informational webinar will be hosted September 6, 2016 from 1pm to 4pm EST. The webinar will provide interested investigators an opportunity to meet and interact with (implementation partners) personnel that have specific expertise in developing spaceflight experiments for the ISS-NL. Additionally a website has been created, http://www.casistissuechip.blogspot.com, to facilitate discussions and distribute information relevant to this initiative.
Research Initiative Details
This Notice encourages investigators with expertise and insights into human microphysiological systems and related technologies that recapitulate human physiology and that can be used to better understand human health and disease to begin to consider applying for this new FOA.
In addition, collaborative investigations combining expertise in materials science, microfabrication, microfluidics, universal media, stem cell technology, tissue engineering, disease modeling, and developing spaceflight experiments for the ISS-NL will be encouraged; these investigators should also begin considering applying for this application.
Among the areas of research encouraged in this initiative are translational research examining the mechanisms that underlie the effects of diseases or conditions associated with bone and cartilage, skeletal muscle, brain, gastrointestinal tract, lung, liver, microvasculature, skin, or other tissues due to prolonged exposure to a microgravity environment, as well as research designed to improve the translation of existing knowledge of strategies for the prevention and treatment of such diseases or conditions.
It is anticipated that the UH2 phase will involve studies on ground development using tissue chip technology under a microgravity environment, flight integration, conducting experiments at the ISS-NL, and post flight analysis. Successful UH2 projects will transition into the UH3 phase for re-flight and additional experiments and analysis.
APPLICATIONS ARE NOT BEING SOLICITED AT THIS TIME.
Please direct all inquiries to:
Danilo A. Tagle, Ph.D.
National Center for Advancing Translational Sciences (NCATS)