Notice of Intent to Publish a Funding Opportunity Announcement for the NIH-CASIS Coordinated Program in Tissue Chip Systems Translational Research in Space(UH2/UH3)
Notice Number: NOT-TR-16-018
Key Dates
Release Date: July 11, 2016
Estimated Publication Date of Announcement: August 2016
First Estimated Application Due Date: December 2016
Earliest Estimated Award Date: July 2017
Earliest Estimated Start Date: August 2017
Related Announcements
Related Announcements
None
Issued by
National Center for Advancing Translational Sciences (NCATS)
Purpose
The National Center for Advancing Translational Sciences (NCATS) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for research on the International Space Station United States National Laboratory (ISS-NL). This opportunity seeks to leverage recent advances in tissue engineering and microfabrication to create microphysiological systems and organ-on-chip technology platforms that recapitulate human physiology to understand the molecular basis of human disease and/or the effectiveness of diagnostic markers and therapeutic intervention for disease treatment. NCATS and the Center for the Advancement of Science in Space (CASIS) share a common interest in translating models of living human tissues on microchips and related novel technologies for the microfabrication of human cell-based systems to the ISS-NL to understand the molecular and cellular basis of human disease in microgravity. CASIS is the nonprofit organization responsible for managing and promoting research onboard the ISS-NL. To that extent, NCATS and CASIS have established a Memorandum of Understanding (MOU) in order to promote communication and interaction among the NIH, CASIS and other research communities, specifically in relation to the NIH NCATS Tissue Chip Program, to facilitate space-related research. Translation of this research to the ISS-NL promises to accelerate the discovery of molecular mechanisms that underlie a range of common human disorders and advance understanding of therapeutic targets and treatments in a reduced fluid shear, microgravity environment that recapitulates cellular and tissue matrices of Earth.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
This FOA will utilize the UH2/UH3 activity code. Details of the planned FOA are provided below.
An informational webinar will be hosted September 6, 2016 from 1pm to 4pm EST. The webinar will provide interested investigators an opportunity to meet and interact with (implementation partners) personnel that have specific expertise in developing spaceflight experiments for the ISS-NL. Additionally a website has been created, http://www.casistissuechip.blogspot.com, to facilitate discussions and distribute information relevant to this initiative.
Research Initiative Details
This Notice encourages investigators with expertise and insights into human microphysiological systems and related technologies that recapitulate human physiology and that can be used to better understand human health and disease to begin to consider applying for this new FOA.
In addition, collaborative investigations combining expertise in materials science, microfabrication, microfluidics, universal media, stem cell technology, tissue engineering, disease modeling, and developing spaceflight experiments for the ISS-NL will be encouraged; these investigators should also begin considering applying for this application.
Among the areas of research encouraged in this initiative are translational research examining the mechanisms that underlie the effects of diseases or conditions associated with bone and cartilage, skeletal muscle, brain, gastrointestinal tract, lung, liver, microvasculature, skin, or other tissues due to prolonged exposure to a microgravity environment, as well as research designed to improve the translation of existing knowledge of strategies for the prevention and treatment of such diseases or conditions.
It is anticipated that the UH2 phase will involve studies on ground development using tissue chip technology under a microgravity environment, flight integration, conducting experiments at the ISS-NL, and post flight analysis. Successful UH2 projects will transition into the UH3 phase for re-flight and additional experiments and analysis.
APPLICATIONS ARE NOT BEING SOLICITED AT THIS TIME.
Inquiries
Please direct all inquiries to:
Danilo A. Tagle, Ph.D.
National Center for Advancing Translational Sciences (NCATS)
Telephone: 301-594-8064
Email: danilo.tagle@nih.gov
Irrespective of receiving daily oral or future injectable depot therapies, these require health care visits for medication and monitoring of safety and response. If patients are treated early enough, before a lot of immune system damage has occurred, life expectancy is close to normal, as long as they remain on successful treatment. However, when patients stop therapy, virus rebounds to high levels in most patients, sometimes associated with severe illness because i have gone through this and even an increased risk of death. The aim of “cure”is ongoing but i still do believe my government made millions of ARV drugs instead of finding a cure. for ongoing therapy and monitoring. ARV alone cannot cure HIV as among the cells that are infected are very long-living CD4 memory cells and possibly other cells that act as long-term reservoirs. HIV can hide in these cells without being detected by the body’s immune system. Therefore even when ART completely blocks subsequent rounds of infection of cells, reservoirs that have been infected before therapy initiation persist and from these reservoirs HIV rebounds if therapy is stopped. “Cure” could either mean an eradication cure, which means to completely rid the body of reservoir virus or a functional HIV cure, where HIV may remain in reservoir cells but rebound to high levels is prevented after therapy interruption.Dr Itua Herbal Medicine makes me believes there is a hope for people suffering from,Parkinson's disease,Schizophrenia,Cancer,Scoliosis,Fibromyalgia,Fluoroquinolone Toxicity
ReplyDeleteSyndrome Fibrodysplasia Ossificans Progressiva.Fatal Familial Insomnia Factor V Leiden Mutation ,Epilepsy Dupuytren's disease,Desmoplastic small-round-cell tumor Diabetes ,Coeliac disease,Creutzfeldt–Jakob disease,Cerebral Amyloid Angiopathy, Ataxia,Arthritis,Amyotrophic Lateral Sclerosis,Alzheimer's disease,Adrenocortical carcinoma.Asthma,Allergic diseases.Hiv_ Aids,Herpes,Inflammatory bowel disease ,Copd,Diabetes,Hepatitis,I read about him online how he cure Tasha and Tara so i contacted him on drituaherbalcenter@gmail.com even talked on whatsapps +2348149277967 believe me it was easy i drank his herbal medicine for two weeks and i was cured just like that isn't Dr Itua a wonder man? Yes he is! I thank him so much so i will advise if you are suffering from one of those diseases Pls do contact him he's a nice man.
My life is beautiful thanks to you, Mein Helfer. Lord Jesus in my life as a candle light in the darkness. You showed me the meaning of faith with your words. I know that even when I cried all day thinking about how to recover, you were not sleeping, you were dear to me. I contacted the herbal center Dr Itua, who lived in West Africa. A friend of mine here in Hamburg is also from Africa. She told me about African herbs but I was nervous. I am very afraid when it comes to Africa because I heard many terrible things about them because of my Christianity. god for direction, take a bold step and get in touch with him in the email and then move to WhatsApp, he asked me if I can come for treatment or I want a delivery, I told him I wanted to know him I buy ticket in 2 ways to Africa To meet Dr. Itua, I went there and I was speechless from the people I saw there. Patent, sick people. Itua is a god sent to the world, I told my pastor about what I am doing, Pastor Bill Scheer. We have a real battle beautifully with Spirit and Flesh. Adoration that same night. He prayed for me and asked me to lead. I spent 2 weeks and 2 days in Africa at Dr Itua Herbal Home. After the treatment, he asked me to meet his nurse for the HIV test when I did it. It was negative, I asked my friend to take me to another nearby hospital when I arrived, it was negative. I was overwhite with the result, but happy inside of me. We went with Dr. Itua, I thank him but I explain that I do not have enough to show him my appreciation, that he understands my situation, but I promise that he will testify about his good work. Thank God for my dear friend, Emma, I know I could be reading this now, I want to thank you. And many thanks to Dr. Itua Herbal Center. He gave me his calendar that I put on my wall in my house. Dr. Itua can also cure the following diseases ... Cancer, HIV, Herpes, Hepatitis B, Inflammatory Liver, Diabetis, Fribroid,Parkinson's disease,Inflammatory bowel disease ,Fibromyalgia, recover your ex. You can contact him by email or whatsapp, @ .. drituaherbalcenter@gmail.com, phone number .. + 2348149277967 .. He is a good doctor, talk to him kindly. I'm sure he will also listen to you.
ReplyDeleteHOW I GOT CURE TO MY HERPES WITH THE HELP OF DR EBAKO NATURAL HERBS CURE WHATSAPP HIM ON +1 (213) 861-9461
ReplyDeleteI can’t believe this. A great testimony that i must share to all HERPES patient in the world i never believed that their could be any complete cure for HERPES or any cure for HERPES,i saw people’s testimony on sites of how DR EBAKO prepare herbal cure and brought them back to life again. i had to try it too and you can,t believe that in just few weeks i started using it all my pains stop gradually and i had to leave without the HERPES DRUGS the doctor gave to me. Right now i can tell you that few months now i have not had any pain,delay in treatment leads to death. Here is his email: doctorebakospellhome@gmail.com his WHATSAPP number is +1 (213) 861-9461
https://drebakocurehome.blogspot.com/
http://drebakocurehome.over-blog.com
he can also cure you from
HPV
HIV
HIV2
Hepatitis B
Diabetes
etc
his Facebook page
@drebakocurehome
............
......
It's indeed a miracle I can't believe am finally free from herpes virus, am grateful to this powerful herbalist called Dr Perfect.
ReplyDeleteI'm Chris Anderson from UK I was sick of herpes for 3 years it affected my relationship with my girlfriend when she find out I was having herpes she left me, I missed her so much because I loved her with all my heart and she always makes me happy she was the source of my happiness I wanted her to come back to me, so I took every treatment and drugs but none could cure my sickness I never lose hope because I believe I will surely get cured and be reunited with my girlfriend again so I went online to search for herpes cure and I came across a comment of a man on how this powerful herbalist cured him of herpes, I didn't hesitate I emailed him and explained my problem to him on how this herpes has affected my relationship he replied my mail and he asked for some information which I gave him and he prepared a herbal cure when he finished preparing the cure he sent it to me and instructed me on how to use it and I did it as I was instructed, five days later I couldn't find any sign of herpes that's was how I was free from herpes virus and he also did a love spell that brought back my ex girlfriend, this was the best thing that have ever happened to me am indeed grateful to Dr Perfect for the help he has rendered to me if you need help to cure your diseases or bring back your ex contact him and get your problems solved at solutiontoallproblems1@gmail.com
You can also add him up on WhatsApp +1 (256)-251-3614
He can also cure the following diseases
1. Herpes virus
2. Chronic venous disease
3. Gonorrhoea
4. Hiv/aids
5. Alzheimers disease
6. Asepsis
7. Cancer
8. Cerebrospinal meingtitis
9. Infertility problems
10. Als/ebv
11. Hpv
12. Enlargement of any type
13. Getting back ex lover/divorce
14. Hepatitis a,b,c
15. Syphilis
16. Arthritis
17. Severe atopic dermatitis
18. Leukaemia/lupus virus and many more....
It's indeed a miracle I can't believe am finally free from herpes virus, am grateful to this powerful herbalist called Dr Perfect.
ReplyDeleteI'm Chris Anderson from UK I was sick of herpes for 3 years it affected my relationship with my girlfriend when she find out I was having herpes she left me, I missed her so much because I loved her with all my heart and she always makes me happy she was the source of my happiness I wanted her to come back to me, so I took every treatment and drugs but none could cure my sickness I never lose hope because I believe I will surely get cured and be reunited with my girlfriend again so I went online to search for herpes cure and I came across a comment of a man on how this powerful herbalist cured him of herpes, I didn't hesitate I emailed him and explained my problem to him on how this herpes has affected my relationship he replied my mail and he asked for some information which I gave him and he prepared a herbal cure when he finished preparing the cure he sent it to me and instructed me on how to use it and I did it as I was instructed, five days later I couldn't find any sign of herpes that's was how I was free from herpes virus and he also did a love spell that brought back my ex girlfriend, this was the best thing that have ever happened to me am indeed grateful to Dr Perfect for the help he has rendered to me if you need help to cure your diseases or bring back your ex contact him and get your problems solved at solutiontoallproblems1@gmail.com
You can also add him up on WhatsApp +1 (256)-251-3614
He can also cure the following diseases
1. Herpes virus
2. Chronic venous disease
3. Gonorrhoea
4. Hiv/aids
5. Alzheimers disease
6. Asepsis
7. Cancer
8. Cerebrospinal meingtitis
9. Infertility problems
10. Als/ebv
11. Hpv
12. Enlargement of any type
13. Getting back ex lover/divorce
14. Hepatitis a,b,c
15. Syphilis
16. Arthritis
17. Severe atopic dermatitis
18. Leukaemia/lupus virus and many more....
I am bold enough among many others to state that there is now a potent cure to this sickness but many are unaware of it. I discovered that I was infected with the virus 3 months ago, after a medical check-up. My doctor told me and I was shocked, confused and felt like my world has crumbled. I was dying slowly due to the announcement of my medical practitioner but he assured me that I could leave a normal life if I took my medications (as there was no medically known cure to Herpes). I went from churches to churches but soon found that my case needed urgent attention as I was growing lean due to fear of dying anytime soon. In a bid to look for a lasting solution to my predicament, I sought for solutions from the herbal world. I went online and searched for every powerful trado-medical practitioner that I could severe, cos I heard that the African Herbs had a cure to the Herpes syndrome. It was after a little time searching the web that I came across one Dr Itua(A powerful African Herbal Doctor), who offered to help me at a monetary fee. I had to comply as this was my final bus-stop to receiving a perfect healing. My last resolve was to take my life by myself, should this plan fail. At last it worked out well. He gave me some steps to follow and I meticulously carried out all his instructions. Last month, to be precise, I went back to the hospital to conduct another test and to my amazement, the results showed that negative,Dr Itua Can As Well Cure The Following Desease…Cancer,Hiv,Herpes, Hepatitis B,Liver Inflammatory,Diabetis,Fribroid,,Non Hodgkin Lymphoma,Skin Cancer,Uterine Cancer,Prostate Cancer Dercum,Infertility,fibromyalgia,Get Your Ex Back,Als,SYPHILLIS,Genetic disease,Epilepsy, Parkinson's disease..You can free yourself of this Herpes virus by consulting this great African Herbal Doctor via this e-mail: drituaherbalcenter@gmail.com or call and whatsapp him on +2348149277967 He will help you and his herb medication is sure. he has the cure on all disease .You can talk to me on INSTAGRAM..tashamoore219....
ReplyDeleteI'm 15 years old. I was born with HIV my mother passed away because of the HIV infection And I regret why i never met Dr Itua he could have cured my mum for me because as a single mother it was very hard for my mother I came across Dr itua healing words online about how he cure different disease in different races diseases like HIV/Aids Herpes,Parkison,Copd,Epilepsy,Shingles,Cold Sore,Infertility, Chronic Fatigues Syndrome,Fibromyalgia, Diabetes Hepatitis even Cancer I was so excited but frighten at same time because I haven't come across such thing article online then I contacted Dr Itua on Mail drituaherbalcenter@gmail.com I also chat with him on what's app +2348149277967 he tells me how it works then I tell him I want to proceed I paid him so swiftly Colorado post office I receive my herbal medicine within 4/5 working days he gave me guild lines to follow and here am I living healthy again can imagine how god use men to manifest his works am I writing in all articles online to spread the god work of Dr Itua Herbal Medicine,He's a Great Man.
ReplyDeletePlay free casino slot machine games for fun at nytopteam.com in July, 2019. Explore more games and slots using the best tips to win.
ReplyDelete
ReplyDeleteI am here to express my profound gratitude for the natural physiotherapy I received from Dr. DADA, After three days of communication, he assure me and send me his Herbal remedy. I have been leaving a healthy life for the last 5 months after completion of my genital and oral herpes treatment with Dr.DADA Natural Healing Medicine, I am now completely free from herpes, after the application and the use of Dr.DADA Medicine. Currently, the only cure for herpes, cancer, diabetes and all other human diseases, I am a living witness of this great miracle, you can contact him on his email address.
(drdadaspellhome7@gmail.com ) OR (drdadaspellhome@hotmail.com) call him or whatsApp him on +2348158568638, Stop Herpes and any other diseases with Dr
DADA herbal remedy. Let’s save life by sharing it on all social networks because God will bless you by sharing this information that will give each patient a new life hope. Thank you for your time..